Asked to think for himself, Al decides not to go with strangers and fight them. However, facing three opponents proves too daunting and Al is forced to go with the kidnappers. Outside, Greed has easily taken care of Ed.

Ed scowers the streets of the town in search of Al but to no avail. Meanwhile, Izumi has arrived at Dante's mansion and questions Dante as to the whereabouts of the brothers. Dante reveals that the kidnappers may be hiding out at a pub called Devil's Nest, and Izumi sets off after them.

At the Devil's Nest, Al finds out that many of Greed's henchmen were made into chimeras at the 5th Laboratory. Greed soon enters and asks Al the answer to eternal life.

In order to convince Al to cooperate, one of Greed's henchmen cuts of Greed's head only to let it reform right before Al's very eyes.

Suddenly, Izumi arrives to rescue Al. Outside, Ed is told by Armstrong that Al should be in the chimera hideout called Devil's Nest which is about to be raided by the military.

In the Devil's Nest, Izumi easily takes care of Greed's henchmen but runs into trouble when she comes upon Greed. Out of nowhere, Ed arrives and tells Greed that he will take Al and Izumi back.

Trying to defeat Greed, Ed and Izumi are held back when Izumi begins to cough up blood again. Instead, Greed and Ed opt for a man-to-man fight. However, their fight is interrupted when the military assaults the chimera hideout.

But before that, Greed shows Ed his serious form and why he is known as the Ultimate Shield.

Kimblee appears before Greed and his gang with Archer by his side. Having been betrayed, Greed is forced to retreat with the remainder of his group.

Wanting to go after them in order to get his little brother back, Ed is detained by the military who is under direct command of Archer.